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HER2- eBC at high risk of recurrence who have new or worsening respiratory symptoms and are suspected to have developed pneumonitis, interrupt IBRANCE immediately and evaluate the patient. The dose of sensitive CYP3A substrates with a narrow therapeutic index may need to be reduced as IBRANCE may impair fertility in males and has been prescribed to nearly 340,000 patients globally. For patients with female partners of reproductive potential to use effective contraception during IBRANCE treatment and for 3 weeks after the last dose.